HNF1B and Familial prostate cancer: Third, the HOT region that harbours prostate cancer-associated SNPs (rs7501939 and rs4430796) in hepatic nuclear factor 1 beta (HNF1b), which has been identified as a major risk gene for prostate cancer by several recent GWA studies47, 60, 61, 62, was found in LNCaP cells but not related healthy cells (Fig. 6C).