Third, the HOT region that harbours prostate cancer-associated SNPs (rs7501939 and rs4430796) in hepatic nuclear factor 1 beta (HNF1b), which has been identified as a major risk gene for prostate cancer by several recent GWA studies47, 60, 61, 62, was found in LNCaP cells but not related healthy cells (Fig. 6C). The gene discussed is HNF1B; the disease is prostate carcinoma.