In particular, features of the mice with IgE-biased immune response induced by cutaneous exposure to agglomerates of allergen and nanoparticles resembled those of humans with atopic allergies, who often have a low IgG/IgE ratio; follow-up epidemiologic studies that focus cutaneous compared with inhalational exposure to nanomaterials might improve our understanding of the onset of atopic allergy. Here, IGHE is linked to atopic IgE-mediated allergic disorder.