SIRT1 and cancer: The evolutionarily conserved NAD+-dependent deacetylase Sirtuin 1 (SIRT1) has been linked to physiology and pathophysiology of central biological processes including cellular stress response, metabolic control, health-span regulation, genome stability, cell death regulation and cancer.1, 2, 3, 4 In accordance with its broad biological functions, a plethora of SIRT1 substrates have been identified.