The proximate study investigated the role of genetic variants of ZFHX3 (zinc finger homeobox 3) in AF, single-nucleotide polymorphism (SNPs) rs2106261 and rs6499600 showed significant associations, and rs16971436 conferred a borderline significant association with risk of AF in Chinese Han populations [13]. The gene discussed is ZFHX3; the disease is atrial fibrillation.