NFKB1 and Alzheimer disease: Wang et al. also showed that 3-N-butylphthalide (NBP) has been reported to attenuate astroglial activation and exert neuroprotective effects in AD transgenic mice by attenuation of Aβ-induced activation of astrocytes and neuroinflammation via inhibition of the NF-κB signaling pathway [48, 49].