We have previously reported higher circulating levels of IL10 in hip fracture patients with new onset of depression (22.41 ± 6.46 pg/ml) compared with hip fracture patients without depression (10.37 ± 2.25 pg/ml) or healthy controls (5.27 ± 1.11 pg/ml) (Duggal et al. 2013a) and here we show a marked increase in IL10 production by CD4 T cells of hip fracture patients with depressive symptoms compared to healthy controls. This evidence concerns the gene IL10 and major depressive disorder.