TUSC2 and neoplasm: Alternatively, as in the case of other 3p21.3 tumor suppressors, like RASSF1A and FUS1, such mechanisms as chromosome instability, aneuploidy, altered RNA splicing, or defects in transcriptional, translational, and posttranslational modifications that are common in the 3p region, may play a role in the inactivation of NPRL1/G21 in lung tumors.