ESR1 and neoplasm: After adjusting to age group, tumor size, histological grade, lymph node status, ER, PR, HER2 status and intrinsic subtype, TNFα GA genotype of TNFα -308G > A SNP remained a significant negative prognostic factor for PFS (P = 0.005, HR = 4.631, 95 % CI = 1.587-13.512), MFS (P = 0.010, HR = 4.708, 95 % CI =1.445 – 15.345) and OS (P = 0.037, HR = 4.829, 95 % CI =1.098 – 21.243), which is shown in Table 5.