However, the data is not consistent [5], poorly differentiated in terms of ethnicity, cancer stage, age etc. This study, therefore, aimed to investigate the relationship between functional SNPs in IL10 and TNFα and BC clinicopathologic features and survival in a highly homogeneous group of patients, taking into account age, race and stage of the disease at the time of diagnosis to identify whether these genetic determinants may be important for BC prognosis. The gene discussed is TNF; the disease is cancer.