Although new antiviral drugs have been developed, the treatment of chronic hepatitis C (CHC) could still be based on a weekly injection of pegylated interferon-α (Peg-IFN-α)-2a or -2b plus a daily weight-based dose of ribavirin depending on the progression of liver damage and the presence of other extrahepatic manifestations [2–5]. This evidence concerns the gene IFNA2 and cryohydrocytosis.