The present study provides preliminary evidence in favor of the GLP-1 based therapies in providing beneficial effects against atherosclerosis as indicated by the significant reductions in atherosclerosis markers including BNP, PAI-1, and hsCRP, besides statistically non-significant reductions in several other markers including IMT, FMD, IL-6, and TNF-α were also noted. This evidence concerns the gene GCG and atherosclerosis.