MKI67 and neoplasm: In their previous publication on the same trial [9], the authors reported significant decreases in weight, body mass index (BMI), glucose, homeostatic model assessment (HOMA), and tumor cell proliferation by Ki-67, as well as an increase in apoptosis by TUNEL (terminal deoxynucleotidyl transferase (TdT) dUTP nick-end labeling) after metformin treatment.