Our finding that AngII and EMA1087 (C21), a small molecule AT2R agonist, caused neurite outgrowth in our assay is in agreement with the neurite promoting effects of C21 previously described in the neuroblastoma-glioma hybrid NG108 cells, that was blocked by the AT2R receptor antagonist (PD-123,319) [15, 23]. Here, AGT is linked to central nervous system cancer.