We next compared OPN serum levels at day 3 of ICU treatment between the different predefined subgroups of ICU patients, namely low vs. high APACHE II scores (Fig. 2b), pre-existing diabetes (Fig. 2c), obesity (Fig. 2d), sepsis (Fig. 2e), or different disease aetiologies (Fig. 2f). The gene discussed is SPP1; the disease is obesity disorder.