ACHE and early-onset autosomal dominant Alzheimer disease: Although the selectivity on AChE over BuChE is a concern for curing Alzheimer’s disease, clinically useful physostigmine (SI = 3.47) [84], galanthamine HBr (SI = 13.1 [86]) and donepezil (SI = 1252 [88]) show selectivity for AChE over BuChE while rivastigmine (SI ≤ 0.008 [86]) and neostigmine (SI = 0.58 [89]) show selectivity for BuChE over AChE.