VEGFA and type 2 diabetes mellitus: The attenuated VEGF signal transduction, or VEGF resistance, has been established as one of the mechanisms underlying the dysfunction of angiogenesis in people with type 2 diabetes.2, 9 Our experiments involving cell migration in vitro and microvessel sprouting from aortic rings ex vivo demonstrated that glycated VN significantly decreased VEGF-induced cell migration and vessel outgrowth.