KRAS and colorectal cancer: This mutually exclusive genomic events have been observed, for example, in the case of BRAF and KRAS (involved in RAS/RAF pathway) in colorectal cancer [97], APC and CTNNB1 (involved in beta catenin pathway) [98], EGFR and KRAS in lung adenocarcinomas [99], TP53 and MDM2 in many different cancer types [100].