IGHE and asthma: In a study of 9 patients with IgG4-related lacrimal gland enlargement, elevated serum IgE levels were found in all patients, and 5 of 9 patients exhibited eosinophilia and asthma-like symptoms, suggesting that a Th2 cell-mediated allergic response may be involved in the pathogenesis of IgG4-related disease [22].