CD8A and influenza: Exercise treatment did not significantly affect the amount of TNFα produced on a per-cell basis as measured by MFI (Fig 9, right).0020Although the significance of the exercise-related difference in the shift toward greater NP-stimulated CD8+ IFNγ+ T cells and fewer CD8+ TNFα+ T cells remains to be established, others have demonstrated that CD8+ TNFα+ T cells contribute to greater influenza-associated immunopathology [40].