These data would suggest that decisions based on a single CD4+ T cell count–to treat HIV infection or to discontinue OI prophylaxis–should consider using a higher absolute CD4+ number (e.g. 233) instead of 200 CD4+ T cells/μl when considering discontinuing OI prophylaxis) to ensure that all subjects with the threshold CD4+ count are included (see Fig 2). This evidence concerns the gene CD4 and HIV infectious disease.