In contrast, mutations in ten eleven translocation 2 (TET2; p = 0.033) and tumor protein p53 (TP53; p = 0.033), as well as the PML-PARA translocation (p = 6.7 * 10−5), which fuses the retinoic acid receptor alpha (RARA) gene on chromosome 17 with the PML gene on chromosome 15 (characteristic for APL), are significantly enriched in AMLs with younger age-predictions. The gene discussed is TP53; the disease is acute promyelocytic leukemia.