Because down-regulation of TNFAIP3 is related to SLE, we further explored the function of Let-7 miRNAs in LN and found that the expression of Let-7 miRNAs and TNFAIP3 in the kidney samples of LN patients was significantly upregulated or decreased compared with normal controls, respectively. This evidence concerns the gene TNFAIP3 and systemic lupus erythematosus.