One patient with BRAFV600E-mutated LCH involving the parietal bone harbored additional variants of unknown significance including BRAF W604C, EGFR (A743V) and cMET (V378I), while another patient with BRAFV600E-mutated LCH had a JAK3 (V722I) mutation. Here, BRAF is linked to Langerhans cell histiocytosis.