Firstly, mRNA transcripts and protein levels were quantified for Rab5, Rab7 and Rab11 in a panel of OSCC cell lines: SCC-9, SCC-25 and OSCC1.2; the later cell line was established from a poorly differentiated and metastatic human oral cancer (stage: T4N2b) with vascular, lymphatic and perineural invasion [32, 33]. This evidence concerns the gene RAB7A and lip and oral cavity carcinoma.