RPS6 and mantle cell lymphoma: Western blot analysis revealed that short-time incubation with acadesine was enough to inhibit the mTOR translational activity, as shown by a decrease in the phosphorylation levels of the mTOR downstream kinase S6 ribosomal protein (p-S6rp) and the eukaryotic translation initiation factor 4E (p-eIF4E) both in MCL cell lines and primary MCL samples (Figure 3A).