10 days post infection (dpi) with shAKTIP, HPFs from healthy individuals displayed a strong reduction in the mitotic index compared to controls (Fig 1A); this reduction was accompanied by a 12 to 18 fold increase in cyclin A levels, and a more modest increase in cyclin E (Fig 1B), indicating a block/delay in cell cycle progression during late S or G2 phases. This evidence concerns the gene CCNA2 and infection.