CREB3L1 and renal cell carcinoma: To determine whether doxorubicin inhibited growth of the tumors that expressed high levels of CREB3L1 by inducing DNA damage, we harvested the xenograft RCC tumors on day 3 after two injections of doxorubicin to measure the amount of histone γH2X, a marker for DNA breaks, by immunoblot analysis.