CDKN2B and neoplasm: ANRIL (1) silences INK4b/ARF/INK4a (a tumor suppressor locus in normal and cancerous cells) by binding to CBX7 (chromobox homolog 7), thereby impacting the ability of CBX7 to repress the function of INK4b/ARF/INK4a and control cell senescence [63] and (2) inactivates p15(INK4B) (a tumor suppressor) by binding to SUZ12 (suppressor of zeste 12 homolog), a subunit of polycomb repressive complex 2, promotes SUZ12 binding to the p15(INK4B) locus, and represses the expression of the p15(INK4B) locus [64].