Studies in HIV-infected patients with OPC [8,11,95] and in CD4C/HIVMutA Tg mice [86] have shown an influx of CD8+ T-cells to the oral mucosa in response to C. albicans infection, suggesting that this cell population may play a role in limiting oral proliferation in the context of CD4+ T-cell deficiency. The gene discussed is CD4; the disease is congenital T-cell immunodeficiency.