INSR and Insulin resistance: A growing body of evidence points to the association of cognitive deficits and insulin resistance in humans and in animals [47–49], an issue that has been poorly explored in the SHR model; a presence of systemic insulin resistance in SHRs has been manifested by a plasma insulin response in 7 week-old animals (sex not specified) [2], and indirectly by a reduced insulin-stimulated glucose transporter bioavailability in adipocytes [50], while an unchanged expression of insulin receptor in the brain of 3-month-old male SHRs was reported by Yang et al. [51].