Not only did the overexpression of LRRC26 result in a reduction of NFkB mRNA levels in MDA-231 cells, it also resulted in the suppression of constitutive NFkB activation and negative regulation of chemokine and cytokine genes and contributed to a tumor microenvironment rich in extracellular matrix components in xenograft models (Liu et al., 2012). This evidence concerns the gene NFKB1 and neoplasm.