Although wild-type and Mutyh-null mice showed a tendency to accumulate DNA 8-oxoG in the gastrointestinal (GI) tract in all treatment conditions, a statistically significant increase was observed only in the AOM/DSS group (2.1-fold and 2.4-fold increases in wild-type and Mutyh-null mice, respectively) (Figure 1D). This evidence concerns the gene MUTYH and infectious otitis media.