The list also included a substantial number of mutations located in well-established cancer- or metastasis-associated genes (Figure 6B): BCL9L [30], DSG2, FLCN, FLNA [31], ITGB4 [32], PIK3CA, PIK3CD [33], PLEC [34], SMAD3, SOX9, SRSF6 [35], TGIF1, and TOP2A [36]. Here, PLEC is linked to cancer.