Importantly, many Class 1-H mutations superimposed with chromosomal deletions were found in the known tumor suppressors, including APC, TP53, SMAD4, and ATM, and the CRC-associated genes, including CSMD1 [19], FLCN [20], and DSG2 [21] (Figure 4D). The gene discussed is SMAD4; the disease is colorectal carcinoma.