Notably, TP53 VAFs from six CRC patients (326, 2557, 9399, 5853, 4989, and 8665) were ~50% in the exomes of CLMs, whereas the VAFs were up to ~100% in the transcriptomes of CLMs (Supplementary Figure S7), suggesting the selective expression of TP53 mutant alleles in CLMs. Here, TP53 is linked to colorectal carcinoma.