In this study of 557 patients with type 2 diabetes, microvascular complications were observed in 6 of 18 (33.3 %) patients on diet only, 102 of 341 (29.9 %) patients on oral antidiabetic drugs, and 138 of 198 (69.6 %) patients on insulin treatment. The gene discussed is INS; the disease is type 2 diabetes mellitus.