The network analysis of three molecules NPM1, RKIP and GRP78 by MetaCore program allowed the addition of two proteins in the context of systems biology, HSPB1 (HSP27) and nucleolin (NCL), interconnected to at least three transcription factors, ESR1, STAT3 and SP1, and downstream of EGFR receptor pathway, classically known as modified in GBM (Fig. 6). This evidence concerns the gene NPM1 and glioblastoma.