PRNP and variant Creutzfeldt-Jakob disease: From this comparative study, two pathological phenotypes were observed in GH-CJDMM1; the first phenotype was characterized by different types of PrP aggregates, including kuru plaques, and some histopathological features of vCJD, such as florid plaques and “stellate” cells highlighted by the pericellular deposition of PrP [16].