PRNP and variant Creutzfeldt-Jakob disease: Three types of abnormal PrP aggregates were observed: i) kuru plaques, occasionally in clusters, in the granular layer and, less commonly, in the cerebral cortex and molecular layer and deep white matter of the cerebellum; ii) kuru plaques surrounded by vacuoles, resembling the florid plaques of variant CJD (vCJD), in the cerebral cortex; iii) eosinophilic plaque-like formations, often populated the superficial cortical layers, were generally larger than, and lacked a dense core and the pale peripheral halo found in, kuru plaques.