PRNP and Creutzfeldt Jacob disease: The detailed pathology of GH-associated CJD (GH-CJD) with methionine (M) homozygous genotype at codon 129 (129MM) of the prion protein (PrP) gene has been reported in 1993–1994 in three French cases who had brain kuru plaques and detectable proteinase K (PK)-resistant PrPSc (resPrPSc) [11] or positive PrP immunostaining [12].