ESR1 and non-small cell lung carcinoma: 5 identified female sex, performance status, weight loss, stage, histology, inter-fraction interval, and treatment as prognostic factors in stage III NSCLC. Mosvas identified QOL as the sole independent prognostic factor in stage III NSCLC patients 9. Additionally, other investigators have identified stage, radiotherapy technique, hoarseness, malaise, erythropoietin, and estrogen receptors in tumor cells as prognostic factors in patients without distant metastases 10–12.