Evidence of “nuclear clearing” of TDP-43 from neurons containing cytoplasmic inclusions, similar to that seen in two-thirds of surviving aggregate containing cells in the TDP-43WTxQ331K animals, has been reported in ALS and FTLD patients [4, 5] and in other mouse models [32, 38]. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.