TARDBP and amyotrophic lateral sclerosis: In the spinal cord of 8 week old TDP-43WTxQ331K mice, TDP-43 staining showed frequent globular cytoplasmic inclusions similar to globular punctate inclusions seen in human TDP-ALS patients [1, 2] (Fig. 3a), which were absent in age matched TDP-43WT and TDP-43Q331K single transgenic and non-transgenic animals (Additional file 1: Figure S3).