It was suggested that other similar proto-oncogenes may exist within the genome and subsequently LMO2 (formerly known as RBTN2, Rhom-2 or Ttg-2) was first discovered through filter hybridization experiments aimed at uncovering additional genes homologous to LMO1 [4] and by direct cloning from the t(11;14)(p13;q11) T-ALL translocation breakpoints [5]. The gene discussed is LMO2; the disease is acute lymphoblastic leukemia.