Brain-derivedneurotrophic factor (BDNF) and its receptors affect the pathogenesis of alcoholism.In this study, we examined the expression of BDNF, tropomyosin receptor kinase B(TrkB) and p75 neurotrophin receptor (p75NTR) in the hippocampus of a dog model ofchronic alcoholism and abstinence. The gene discussed is BDNF; the disease is alcohol drinking.