These protumorigenic neutrophils supportextravasation, survival, growth, and establishment of metastatic tumor cells.Pretreatment of animals with rG-CSF (recombinant murine protein) is sufficient to mimicthe neutrophil expansion and the pre-metastatic microenvironment initiated by theprimary tumor, reinforcing the proposed role of tumor-produced G-CSF (65). Here, CSF3 is linked to neoplasm.