MDSCare generated in bone marrow in response to factors secreted by tumor cells themselves,such as G-CSF, GM-CSF, IL-6, IL-1β, prostaglandin (PG) E2, VEGF, and TNF-α, and arerecruited to the site of the primary tumor and secondary lymphoid organs (lymph nodes,spleen) by chemokines such as CCL2, CXCL12, and CXCL5. This evidence concerns the gene CCL2 and neoplasm.