UCP2 and breast carcinoma: Moreover, it was also observed that the IC50 of Doxorubicin in MCF-7/Dox transduced with UCP-2 shRNA was significantly lower than that in MCF-7/Dox transduced with shScramble as well as in the parental cells (Fig 3B), which further suggested that UCP-2 plays an essential role in the development of Doxorubicin resistance in breast cancer cells MCF-7.