CD4 and neoplasm: On the other hand, IL-2 increased overall tumor cytokine secretion with no clear bias toward pro-inflammatory or anti-tumor phenotype (Fig 2A–2H), and IL-2 injections increased the relative amount of Foxp3+ CD25+ CD4+ regulatory T-cells in the tumors (Fig D in S3 Fig), suggesting simultaneous induction of both anti-tumor and immunosuppressive pathways.