When we investigated the interaction of rs10930781 in the NRF2 gene and the other single nucleotide polymorphism (rs11545829) in the KEAP1 gene on intellectual functions in patients with schizophrenia, we found similar results to the above interactions observed for working memory (P = 0.012) and processing speed (P = 0.0024) (Fig 6B and S2 Table). Here, KEAP1 is linked to schizophrenia.