IGF1R and cervical squamous intraepithelial neoplasia: Signalling via the IGF1R pathway has been proposed to be an important determinant of cervical cancer progression, since elevated expression of IGF1R has been observed in cervical specimens which positively correlated with stage of the CIN lesions [13,39] and further highlights the importance of the IGF-axis in HPV infection and incidence of CIN lesions [49].