In order to establish the clinical relevance of our findings, expression of IGFBP2 was assessed in pre-malignant cervical intraepithelial neoplasia’s (CIN) by immunohistochemistry and dual immunofluorescence, utilising p16INK4A (p16) staining to distinguish premalignant cells from normal cells. Here, CDKN2A is linked to cervical squamous intraepithelial neoplasia.