We next focused on these five miRNAs, and examined their potential association with clinical parameters of PCa progression, including biochemical recurrence (two consecutive PSA values >0.2 ng/ml during follow-up), Gleason score (GS ≤7 vs GS >7), tumor size (T2 vs T3-T4 PCa) and lymph nodes metastases. This evidence concerns the gene KLK3 and posterior cortical atrophy.