The relative percentages and absolute numbers of blood CD20+CD27+CD21hiIgM- switched memory, CD20+CD27-IgM+CD21hiCD10- naïve, CD20+CD27-IgM+CD21+CD10+ TI, CD20+CD27+IgMhiCD21hiCD1c+ CD10- mature MZ-like and CD20+CD27+IgMhiCD21loCD1c+CD10+ precursor MZ-like B-cells at all time points following infection were below pre-infection levels albeit we observed a trend towards restoration of these B-cell populations in the chronic phase of infection for most animals (Fig 5C–5G). The gene discussed is CR2; the disease is infection.