In particular, we highlight and prefer a two SNP model for MS association to the IL2RA region, one of the SNPs shared with T1D (group A, indexed by rs12722495) and associated with CD25 expression on memory T cells, the other (group D, indexed by rs41295055) a better predictor for CD25 expression on the surface of naive CD4+ T cells than the SNP identified by stepwise regression (group C, rs2104286). The gene discussed is CD4; the disease is type 1 diabetes mellitus.