However, this disease is one of the most common opportunistic infections among HIV/AIDS patients with CD4+ T lymphocytes below 150 cells/μL (known as AIDS-definitory condition), who may develop severe and fatal disseminated histoplasmosis [59]; approximately 30% of these patients die from this infection [74–76]. H. capsulatum infections have also been described in patients with transplants [77, 78], invasive devices, and/or surgical implants [79–81]. This evidence concerns the gene CD4 and infection.