Acral melanomas exhibited differential methylation at the gene bodies of MGMT (4% hypomethylation in acral melanoma group, P = 7e − 3, Supplementary Table 4) and TERT (9% hypermethylation in acral melanoma group, P < 1e − 3, Supplementary Table 4) compared to nonacral tumors. Here, MGMT is linked to melanoma.