MITF and melanoma: We did not find significant differences comparing tumors from patients who did develop or not metastases (Supplementary Table 5); however, in the analysis of the seven paired primary-metastasis melanoma samples, the gene body of MITF was found to be hypomethylated in metastasis (8% of decreased methylation in relation to primary tumor, P = 0.02, Supplementary Table 6).