Expression of MT1-MMP together with nuclear β-catenin and the MT1-MMP substrate laminin-2 chain at the leading edge of invasive CRC has been previously described [23]; additionally, the authors of that study showed β-catenin-mediated activation of MT1-MMP transcription in CRC cells in vitro, confirming similar results from a previous paper [22]. This evidence concerns the gene MMP14 and colorectal carcinoma.